Your period back on its own, the sugar cravings gone, and a cycle you can count on without the pill.
Regular Cycles, Fewer Cravings & Calmer PCOS Symptoms
Trusted by 50,000+ customersTake two with breakfast and two with dinner for 30 days. Watch your cravings, your energy, your skin and your calendar. If you are not glad you bought it, send us a message and you get a full refund. Nothing to ship back.
Myo-inositol rebuilds the insulin signal. Myo is the raw material for the messengers your cells use to answer insulin. Women with PCOS run short of it. 2,000 mg a day, split in two, is the most studied dose for getting a cycle back.
D-chiro helps the sugar get used. D-chiro handles how glucose gets stored and burned. The body only wants a little of it. Too much works against egg quality, so it is 50 mg here and no more.
The 40:1 ratio keeps the ovaries in balance. Healthy blood holds myo to D-chiro at about 40 to 1. The studies that shortened cycles and brought ovulation back used that ratio. Four capsules give you exactly that.
Every order ships free and tracked from our US warehouse, and the tracking number is emailed the moment it leaves. You have 30 days from delivery to decide. If it is not for you, send us a message and you get every cent back, with nothing to ship back.
Most "did nothing" stories are the wrong bottle. Plain myo with no D-chiro, half a scoop when she remembered, for five weeks. That is not the dose or the time the studies used. 2,000 mg plus 50 mg, every day, for three months is.
Give it the time the studies gave it. Cravings shift in weeks. A cycle takes two to three months to change, because a cycle takes that long to run. In month one, watch your calendar, not the mirror.
If it is not for you, you pay nothing. Finish the bottle. If you are not glad you bought it, send us a message within 30 days of delivery and every cent comes back. Nothing to ship back.
| Myo-Inositolpure myo-inositol | 2,000 mg |
| D-Chiro-Inositolpure D-chiro-inositol, 40:1 ratio with myo-inositol | 50 mg |
Other ingredients: vegetable cellulose capsule.
Take 2 capsules with breakfast and 2 capsules with dinner. New to inositol? Take 2 a day with food for the first week, then go to 4. Do not exceed 4 capsules in 24 hours.
How much inositol is really in each capsule?
500 mg of myo-inositol and 12.5 mg of D-chiro-inositol per capsule. Four capsules a day give you 2,000 mg of myo and 50 mg of D-chiro, the exact 40:1 ratio. Each one has its own line on the Supplement Facts panel, not one "inositol blend" line with the ratio left to your imagination.
Would I be able to take it while taking metformin? What about birth control, letrozole or Clomid?
Many women take inositol alongside metformin, and many take it with birth control or during a letrozole or Clomid cycle. The studies were run on women like them. It does not stop the pill from working. Tell your doctor or OB you are taking it and bring the bottle. Everything in it is on the label.
Are there any side effects? What does the first week feel like?
Most women feel nothing at all when they take it with meals. A few get a headache, feel sleepy or a little queasy the first few days, and it passes within a week. If you want to ease in, take two a day with food for the first week, then go to four. Never take it on an empty stomach.
Has anyone had a delay, or a heavy period, when starting it?
Yes, and it is the number one reason women quit too early. The first period back often comes early, runs heavier or longer than you remember, or comes with some spotting. It settles by the second cycle. If bleeding runs past two weeks, call your OB, and keep taking it.
How long after taking it did you get your cycle back and ovulate?
Cravings and energy shift in the first two to three weeks. The first period back usually shows up in weeks four to eight. Cycle length and ovulation signs, like dark LH strips, change in months two and three. The PCOS studies ran 12 weeks, which is why the 3-bottle pack is the one most women choose.
Is there any particular point in my cycle when it is best to start taking it?
No. Start now, whatever day you are on, and keep taking it during your period. Skipped days are the main reason it stops working for people, so keep it next to your toothbrush or in a pill case.
I have lean or adrenal PCOS. Will the D-chiro make it worse?
That worry comes from high-D-chiro products, where D-chiro is a big share of the dose. Here it is 50 mg against 2,000 mg of myo, the same 40:1 your body keeps on its own. If your RE has told you to take myo only, follow your RE.
Did inositol also help you with weight loss if you were overweight?
It is not a diet pill. What women report is that the sugar cravings and the food noise drop, so the walking and the eating changes they were already doing finally show. Waist first, usually in month two. A small number of women report extra hunger or water weight in the first weeks. Taking it with the evening meal fixed it for most.
Do you keep taking it once you get your BFP, or do you stop?
Many women keep taking it through the first trimester, and many REs tell them to. Ask yours. Everything in the bottle is on the label, so it is a quick answer.
How do I know there is D-chiro in there and not just cornstarch?
Every batch is checked by an independent US lab for both inositols, the ratio, heavy metals and purity. The lot number and the date are on every bottle, and every bottle is a full 120 count.
Can I take Berberine with Inositol?
Yes. Many women pair them: inositol for the cycle and the insulin signal, berberine for after-meal blood sugar and cravings. Take both with food.
What if it does not work for me?
You have 30 days from delivery. Finish the bottle, and if you are not happy, send us a message and every cent comes back. You do not need to ship anything back.
I was sure I would be the one it did nothing for, like half of Reddit. I gave it the three months everyone says to give it. I only needed two.Hannah D. · Austin
From customers
cd 33 again. i can count on it now
month two. jeans button again
sunday pill case, two and two
cycle 2, dark again. on my own
What 1,912 customers say
From 1,912 verified Myo & D-Chiro Inositol reviews.
Why it keeps happening
You have gone 60, 90, 120 days without a period. The cystic acne came back the month you came off the pill. You eat less than everyone at the table and the weight still will not move. None of that is a discipline problem. It is an insulin problem. With PCOS your cells stop hearing insulin, so your body makes more of it. High insulin tells your ovaries to make extra testosterone and skip ovulation. That is the chin hair, the acne, the cravings and the belly, all from one root.
Then the doctor offers birth control to "regulate" it, or metformin, or "lose weight and come back". Nobody mentions that your cells use a nutrient called inositol to hear insulin, and that women with PCOS run short of it. Putting it back, at the right dose and the right ratio, is what the PCOS studies did.
A scheduled bleed is not a cycle. It covers the problem and does nothing for the insulin, the cravings or the chin hair. Come off it and everything comes back.
The runs, the nausea, and a doctor who never checked your insulin in the first place. Women call inositol natural metformin for a reason.
No D-chiro, no ratio on the label, a scoop that will not mix. You cannot take what you keep forgetting in the cabinet.
How it works
Two ingredients at the study dose. Nothing else in the capsule.
Myo is the raw material for the messengers your cells use to answer insulin. Women with PCOS run short of it. 2,000 mg a day, split in two, is the most studied dose for getting a cycle back.
D-chiro handles how glucose gets stored and burned. The body only wants a little of it. Too much works against egg quality, so it is 50 mg here and no more.
Healthy blood holds myo to D-chiro at about 40 to 1. The studies that shortened cycles and brought ovulation back used that ratio. Four capsules give you exactly that.
Supports healthy insulin sensitivity, ovarian function and a regular cycle, and healthy blood sugar levels already within the normal range. Not a replacement for medication.
What changes
Inositol is the most studied supplement for PCOS. Here is what changes, in the order women report it.
Most women feel this first, in the first two to three weeks. Hungry like a normal person again. Dessert stops being a fight you lose every night.
Women who had gone months without one report it showing up in month two or three. Then the gap shrinks: 58 days, then 44, then 32.
When your cells hear insulin again, your body stops storing everything around your middle. The gym and the salads finally count for something.
The hormonal breakouts and the chin hairs slow down over months four to six. Less of the fog and the short fuse before your period.
What is in it
The Supplement Facts panel from the bottle. Look for two separate lines, not one "inositol blend" line.
Serving size 4 capsulesServings per container 30
| Amount per serving | % DV |
|---|---|
| Myo-Inositolpure myo-inositol | 2,000 mg† |
| D-Chiro-Inositolpure D-chiro-inositol, 40:1 ratio with myo-inositol | 50 mg† |
† Daily Value not established.
Other ingredients: vegetable cellulose capsule.
Directions: Take 2 capsules with breakfast and 2 capsules with dinner. New to inositol? Take 2 a day with food for the first week, then go to 4. Do not exceed 4 capsules in 24 hours.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
A clinician’s view
Fourteen years in women’s health, most of it with PCOS patients who were told to lose weight and come back. Here is what she tells them.
When a patient tells me inositol did nothing for her, I ask three things. Did the bottle have D-chiro in it, and how much. Did she take 2,000 milligrams of myo a day, every day. And did she give it three months. Usually the answer is a tub of plain myo from Amazon, half a scoop when she remembered, for five weeks. So I tell her what to look for: both inositols on the label with their own numbers, 40 to 1, in a capsule she will take with meals. This bottle has the 2,000 and the 50 on the front. I also tell her the first period back can be heavy, and to call me instead of stopping.
What to expect
Everyone is different. This is the pattern in the reviews.
Two with breakfast, two with dinner, always with a meal. A few women get a headache or feel sleepy the first days. It passes by day five or so. Start with two a day if you are nervous.
The sugar cravings and the late-night hunger ease. Sleep gets deeper. Some women see their skin start to settle.
Many women get their first period in months here. The first one can come early, run heavy or run long. That is normal, and it settles by the second.
The PCOS studies ran 12 weeks. By now cycles are shorter and ovulation tests turn dark. By month six the chin hairs and the breakouts slow down.
Compare before you buy
What the typical inositol on the shelf leaves out.
| Compare | Myo & D-Chiro Inositol | Typical inositol capsules and powders |
|---|---|---|
| Ratio | 40:1, both numbers on the front | Plain myo, or a blend with no numbers |
| D-chiro-inositol | 50 mg, its own line on the label | Missing, or hidden in a "proprietary blend" |
| Myo-inositol per day | 2,000 mg, the study dose | 1,000 mg unless you double up |
| Capsules a day | 4, two with each meal, no taste | 4 large ones that come back up, or 8 |
| Powder problems | None. No scoop, no shaker, no taste | Will not mix, "sickeningly sweet", scoop buried in the tub |
| The bottle | 120 counted, lot-dated, full | Half full, expired, "sometimes I am left with one" |
| Guarantee | 30 days, money back, no return | Marketplace returns, if any |
Customer reviews
1,912 verified reviews
Seven months without a period and my OB kept pushing the pill. I ordered these off a What to Expect thread instead. Day 52, two in the morning and two at night, it showed up. Then again 33 days later. I cried in the Target bathroom. Sticking with it through the winter.
Insulin resistant, not PCOS, and always hungry even on low carb. My thing was standing in the pantry at 9 every night eating crackers out of the sleeve. Three weeks in I just stopped doing it. Fasting insulin came back 11 from 19 at my follow-up and I’m down 7 pounds without changing my workouts. If I skip a few days I can tell.
My gaps went from 45 to 60 days down to 34 and then 32 in the first two months. That never happened on the powder I kept forgetting in the cabinet. One star off because four a day is four a day, as every PCOS girly with a drawer full of supplements knows. I take them in two gulps and keep two in my purse for when I skip breakfast. Still ordering.
Went through two tubs of powder that lived half used in my gym bag because it would not mix and I could taste it in my coffee. These sit in my weekly pill case next to my vitamin D and I haven’t skipped a day in ten weeks. The chin breakouts before my period are mostly gone. One spot this month, you can see it, and that used to be five.
Diagnosed at 29 and told to lose weight by a doctor who could not tell me why it was so hard for me. Two months on these plus the gym three times a week and my waist is down two inches. My sister noticed before I did. The cravings before my period are a whisper now. I take them with the Dosera berberine.
Over a year of trying and my LH strips never once went dark, so I figured I was not ovulating at all. Month three on these I got a blaring positive on day 16. My husband framed the strip, which is ridiculous, and it’s on the coffee table now. No stomach trouble, which I was nervous about after reading the Amazon reviews. Baby dust to whoever is reading this.
period came back
No taste, easy to swallow.
3 weeks in, cravings def down. cycle tbd.
Headache the first few days, gone by day five. Stick with it.
Box showed up crushed but the bottle was fine. Cycle was 36 days, first time under 40 in years.
I brought the bottle to my appointment. She read the label, said the numbers matched what she had seen in the research, and told me to keep going.
Tell other people what changed for you.
The question everyone asks
It is the top worry on every PCOS thread, and it is a fair one. Here is the straight answer.
Plain myo with no D-chiro, half a scoop when she remembered, for five weeks. That is not the dose or the time the studies used. 2,000 mg plus 50 mg, every day, for three months is.
Cravings shift in weeks. A cycle takes two to three months to change, because a cycle takes that long to run. In month one, watch your calendar, not the mirror.
Finish the bottle. If you are not glad you bought it, send us a message within 30 days of delivery and every cent comes back. Nothing to ship back.
Your guarantee
Take two with breakfast and two with dinner for 30 days. Watch your cravings, your energy, your skin and your calendar. If you are not glad you bought it, send us a message and you get a full refund. Nothing to ship back.
Full refund, no return needed, no questions.
Both inositols, the 40:1 ratio, heavy metals and purity checked by an independent US lab.
Tracked from our US warehouse. Tracking number emailed the moment it ships.
Before or after you buy: [email protected]. Someone answers around the clock.
Pairs well with
Inositol works on the insulin signal. Women who pair it with Berberine report the biggest change in cravings and waistline.
Berberine HCl CapsulesLower fasting numbers, fewer cravings, no afternoon crash.From $26.66 / bottle
Ceylon Cinnamon CapsulesSmaller spikes after meals and a lower morning number. True Ceylon, so your liver is not paying for it.From $23.33 / bottle
Alpha-Lipoic Acid CapsulesBurning, tingling feet quiet down at night. Numb toes feel the floor again.From $23.33 / bottle
Gymnema Complex CapsulesThe after-dinner sweet tooth goes quiet. Sugar cravings fade in about two weeks.From $20.00 / bottleCommon questions
500 mg of myo-inositol and 12.5 mg of D-chiro-inositol per capsule. Four capsules a day give you 2,000 mg of myo and 50 mg of D-chiro, the exact 40:1 ratio. Each one has its own line on the Supplement Facts panel, not one "inositol blend" line with the ratio left to your imagination.
Many women take inositol alongside metformin, and many take it with birth control or during a letrozole or Clomid cycle. The studies were run on women like them. It does not stop the pill from working. Tell your doctor or OB you are taking it and bring the bottle. Everything in it is on the label.
Most women feel nothing at all when they take it with meals. A few get a headache, feel sleepy or a little queasy the first few days, and it passes within a week. If you want to ease in, take two a day with food for the first week, then go to four. Never take it on an empty stomach.
Yes, and it is the number one reason women quit too early. The first period back often comes early, runs heavier or longer than you remember, or comes with some spotting. It settles by the second cycle. If bleeding runs past two weeks, call your OB, and keep taking it.
Cravings and energy shift in the first two to three weeks. The first period back usually shows up in weeks four to eight. Cycle length and ovulation signs, like dark LH strips, change in months two and three. The PCOS studies ran 12 weeks, which is why the 3-bottle pack is the one most women choose.
No. Start now, whatever day you are on, and keep taking it during your period. Skipped days are the main reason it stops working for people, so keep it next to your toothbrush or in a pill case.
That worry comes from high-D-chiro products, where D-chiro is a big share of the dose. Here it is 50 mg against 2,000 mg of myo, the same 40:1 your body keeps on its own. If your RE has told you to take myo only, follow your RE.
It is not a diet pill. What women report is that the sugar cravings and the food noise drop, so the walking and the eating changes they were already doing finally show. Waist first, usually in month two. A small number of women report extra hunger or water weight in the first weeks. Taking it with the evening meal fixed it for most.
Many women keep taking it through the first trimester, and many REs tell them to. Ask yours. Everything in the bottle is on the label, so it is a quick answer.
Every batch is checked by an independent US lab for both inositols, the ratio, heavy metals and purity. The lot number and the date are on every bottle, and every bottle is a full 120 count.
Yes. Many women pair them: inositol for the cycle and the insulin signal, berberine for after-meal blood sugar and cravings. Take both with food.
You have 30 days from delivery. Finish the bottle, and if you are not happy, send us a message and every cent comes back. You do not need to ship anything back.
Stop counting cycle days and hoping. Stop losing every night to the sugar cravings. Four capsules a day, 2,000 mg myo and 50 mg D-chiro, the exact 40:1 the PCOS studies used. Ships free from our US warehouse, with 30 days to be sure.
